Dual-target anti-Alzheimer’s disease agents with both iron ion chelating and monoamine oxidase-B inhibitory activity

Dual-target anti-Alzheimer’s disease agents with both iron ion chelating and monoamine oxidase-B inhibitory activity

MAO-B leads to an increase in the levels of hydrogen peroxide and oxidative free radicals, which contribute to the aetiology of the AD. Thus, both iron ion chelators and MAO-B inhibitors can be used to treat AD. Taking the coumarin derivatives and hydroxypyridinones as the lead compounds, a series o...

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Bibliographic Details
Main Authors: Zhisheng Mi, Bing Gan, Sihang Yu, Jianan Guo, Changjun Zhang, Xiaoying Jiang, Tao Zhou, Jing Su, Renren Bai, Yuanyuan Xie
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
alzheimer’s disease
iron ion chelation
mao-b
coumarin derivatives
hydroxypyridinone
Online Access:http://dx.doi.org/10.1080/14756366.2019.1634703

Internet

http://dx.doi.org/10.1080/14756366.2019.1634703

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