Serum Peak Sulfamethoxazole Concentrations Demonstrate Difficulty in Achieving a Target Range: A Retrospective Cohort Study

Objectives: Trimethoprim (TMP)/sulfamethoxazole (SMX) has consistently demonstrated great interindividual variability. Therapeutic drug monitoring may be used to optimize dosing. Optimal peak SMX concentration has been proposed as 100 to 150 μg/mL. The objective of our work was to determine the succ...

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Bibliographic Details
Main Authors: Bao D. Dao, PharmD, Jason N. Barreto, PharmD, Robert C. Wolf, PharmD, Ross A. Dierkhising, MS, Matthew F. Plevak, BS, Pritish K. Tosh, MD
Format: Article
Language:English
Published: Elsevier 2014-12-01
Series:Current Therapeutic Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0011393X14000204