A novel hypomorphic allele of Spag17 causes primary ciliary dyskinesia phenotypes in mice

A novel hypomorphic allele of Spag17 causes primary ciliary dyskinesia phenotypes in mice

Primary ciliary dyskinesia (PCD) is a human condition of dysfunctional motile cilia characterized by recurrent lung infection, infertility, organ laterality defects and partially penetrant hydrocephalus. We recovered a mouse mutant from a forward genetic screen that developed many of the hallmark ph...

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Bibliographic Details
Main Authors: Zakia Abdelhamed, Marshall Lukacs, Sandra Cindric, Heymut Omran, Rolf W. Stottmann
Format: Article
Language:English
Published: The Company of Biologists 2020-10-01
Series:Disease Models & Mechanisms
Subjects:
cilia
hydrocephalus
infertility
lung
primary ciliary dyskinesia
spag17
Online Access:http://dmm.biologists.org/content/13/10/dmm045344

Internet

http://dmm.biologists.org/content/13/10/dmm045344

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