Nestin regulates cellular redox homeostasis in lung cancer through the Keap1–Nrf2 feedback loop
Loss of Nestin sensitizes non-small cell lung carcinoma (NSCLC) to oxidative stress. Here, the authors report a feedback loop between Nestin and Nrf2 wherein Nestin competes with Nrf2 for Keap1 binding, preventing Nrf2 degradation, and show the Nestin–Keap1–Nrf2 axis to regulate redox homeostasis in...
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Nature Publishing Group
2019-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-12925-9 |
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doaj-b1b00c42536b4061b50abe0984df25052021-05-11T11:59:14ZengNature Publishing GroupNature Communications2041-17232019-11-0110111710.1038/s41467-019-12925-9Nestin regulates cellular redox homeostasis in lung cancer through the Keap1–Nrf2 feedback loopJiancheng Wang0Qiying Lu1Jianye Cai2Yi Wang3Xiaofan Lai4Yuan Qiu5Yinong Huang6Qiong Ke7Yanan Zhang8Yuanjun Guan9Haoxiang Wu10Yuanyuan Wang11Xin Liu12Yue Shi13Kang Zhang14Maosheng Wang15Andy Peng Xiang16Program of Stem Cells and Regenerative Medicine, Affiliated Guangzhou Women and Children’s Hospital, Zhongshan School of Medicine, Sun Yat-Sen UniversityProgram of Stem Cells and Regenerative Medicine, Affiliated Guangzhou Women and Children’s Hospital, Zhongshan School of Medicine, Sun Yat-Sen UniversityCenter for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen UniversityProgram of Stem Cells and Regenerative Medicine, Affiliated Guangzhou Women and Children’s Hospital, Zhongshan School of Medicine, Sun Yat-Sen UniversityDepartment of Anesthesiology, The First Affiliated Hospital of Sun Yat-sen UniversityProgram of Stem Cells and Regenerative Medicine, Affiliated Guangzhou Women and Children’s Hospital, Zhongshan School of Medicine, Sun Yat-Sen UniversityCenter for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen UniversityProgram of Stem Cells and Regenerative Medicine, Affiliated Guangzhou Women and Children’s Hospital, Zhongshan School of Medicine, Sun Yat-Sen UniversityProgram of Stem Cells and Regenerative Medicine, Affiliated Guangzhou Women and Children’s Hospital, Zhongshan School of Medicine, Sun Yat-Sen UniversityCore Facility of Center, Zhongshan School of Medicine, Sun Yat-Sen UniversityCenter for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen UniversityCenter for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen UniversityCenter for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen UniversityCenter for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen UniversityFaculty of Medicine, Macau University of Science and TechnologyThe Cardiovascular Center, Gaozhou People’s HospitalProgram of Stem Cells and Regenerative Medicine, Affiliated Guangzhou Women and Children’s Hospital, Zhongshan School of Medicine, Sun Yat-Sen UniversityLoss of Nestin sensitizes non-small cell lung carcinoma (NSCLC) to oxidative stress. Here, the authors report a feedback loop between Nestin and Nrf2 wherein Nestin competes with Nrf2 for Keap1 binding, preventing Nrf2 degradation, and show the Nestin–Keap1–Nrf2 axis to regulate redox homeostasis in NSCLC.https://doi.org/10.1038/s41467-019-12925-9 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Jiancheng Wang Qiying Lu Jianye Cai Yi Wang Xiaofan Lai Yuan Qiu Yinong Huang Qiong Ke Yanan Zhang Yuanjun Guan Haoxiang Wu Yuanyuan Wang Xin Liu Yue Shi Kang Zhang Maosheng Wang Andy Peng Xiang |
| spellingShingle |
Jiancheng Wang Qiying Lu Jianye Cai Yi Wang Xiaofan Lai Yuan Qiu Yinong Huang Qiong Ke Yanan Zhang Yuanjun Guan Haoxiang Wu Yuanyuan Wang Xin Liu Yue Shi Kang Zhang Maosheng Wang Andy Peng Xiang Nestin regulates cellular redox homeostasis in lung cancer through the Keap1–Nrf2 feedback loop Nature Communications |
| author_facet |
Jiancheng Wang Qiying Lu Jianye Cai Yi Wang Xiaofan Lai Yuan Qiu Yinong Huang Qiong Ke Yanan Zhang Yuanjun Guan Haoxiang Wu Yuanyuan Wang Xin Liu Yue Shi Kang Zhang Maosheng Wang Andy Peng Xiang |
| author_sort |
Jiancheng Wang |
| title |
Nestin regulates cellular redox homeostasis in lung cancer through the Keap1–Nrf2 feedback loop |
| title_short |
Nestin regulates cellular redox homeostasis in lung cancer through the Keap1–Nrf2 feedback loop |
| title_full |
Nestin regulates cellular redox homeostasis in lung cancer through the Keap1–Nrf2 feedback loop |
| title_fullStr |
Nestin regulates cellular redox homeostasis in lung cancer through the Keap1–Nrf2 feedback loop |
| title_full_unstemmed |
Nestin regulates cellular redox homeostasis in lung cancer through the Keap1–Nrf2 feedback loop |
| title_sort |
nestin regulates cellular redox homeostasis in lung cancer through the keap1–nrf2 feedback loop |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2019-11-01 |
| description |
Loss of Nestin sensitizes non-small cell lung carcinoma (NSCLC) to oxidative stress. Here, the authors report a feedback loop between Nestin and Nrf2 wherein Nestin competes with Nrf2 for Keap1 binding, preventing Nrf2 degradation, and show the Nestin–Keap1–Nrf2 axis to regulate redox homeostasis in NSCLC. |
| url |
https://doi.org/10.1038/s41467-019-12925-9 |
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