Nestin regulates cellular redox homeostasis in lung cancer through the Keap1–Nrf2 feedback loop

Nestin regulates cellular redox homeostasis in lung cancer through the Keap1–Nrf2 feedback loop

Loss of Nestin sensitizes non-small cell lung carcinoma (NSCLC) to oxidative stress. Here, the authors report a feedback loop between Nestin and Nrf2 wherein Nestin competes with Nrf2 for Keap1 binding, preventing Nrf2 degradation, and show the Nestin–Keap1–Nrf2 axis to regulate redox homeostasis in...

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Bibliographic Details
Main Authors: Jiancheng Wang, Qiying Lu, Jianye Cai, Yi Wang, Xiaofan Lai, Yuan Qiu, Yinong Huang, Qiong Ke, Yanan Zhang, Yuanjun Guan, Haoxiang Wu, Yuanyuan Wang, Xin Liu, Yue Shi, Kang Zhang, Maosheng Wang, Andy Peng Xiang
Format: Article
Language:English
Published: Nature Publishing Group 2019-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-12925-9

Internet

https://doi.org/10.1038/s41467-019-12925-9

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