pTuneos: prioritizing tumor neoantigens from next-generation sequencing data

pTuneos: prioritizing tumor neoantigens from next-generation sequencing data

Abstract Background Cancer neoantigens are expressed only in cancer cells and presented on the tumor cell surface in complex with major histocompatibility complex (MHC) class I proteins for recognition by cytotoxic T cells. Accurate and rapid identification of neoantigens play a pivotal role in canc...

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Bibliographic Details
Main Authors: Chi Zhou, Zhiting Wei, Zhanbing Zhang, Biyu Zhang, Chenyu Zhu, Ke Chen, Guohui Chuai, Sheng Qu, Lu Xie, Yong Gao, Qi Liu
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Genome Medicine
Subjects:
Cancer neoantigen
Next-generation sequencing
Immune checkpoint blockade
Biomarker
Immunotherapy
Online Access:http://link.springer.com/article/10.1186/s13073-019-0679-x

Internet

http://link.springer.com/article/10.1186/s13073-019-0679-x

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