The In Vivo Effect of Transcellular Permeation Enhancers on the Intestinal Permeability of Two Peptide Drugs Enalaprilat and Hexarelin

The In Vivo Effect of Transcellular Permeation Enhancers on the Intestinal Permeability of Two Peptide Drugs Enalaprilat and Hexarelin

Permeation enhancers like sodium dodecyl sulfate (SDS) and caprate increase the intestinal permeability of small model peptide compounds, such as enalaprilat (349 Da). However, their effects remain to be investigated for larger low-permeability peptide drugs, such as hexarelin (887 Da). The objectiv...

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Bibliographic Details
Main Authors: David Dahlgren, Markus Sjöblom, Mikael Hedeland, Hans Lennernäs
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Pharmaceutics
Subjects:
permeation enhancers
absorption-modifying excipients
oral peptide delivery
intestinal permeability
intestinal perfusion
pharmaceutical development
Online Access:https://www.mdpi.com/1999-4923/12/2/99

Internet

https://www.mdpi.com/1999-4923/12/2/99

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