cGAS/STING: novel perspectives of the classic pathway

cGAS/STING: novel perspectives of the classic pathway

Abstract Cyclic GMP-AMP (cGAMP) synthase (cGAS) is a cytosolic DNA sensor and innate immune response initiator. Binding with exogenous or endogenous nucleic acids, cGAS activates its downstream adaptor, stimulator of interferon genes (STING). STING then triggers protective immune to enable the elimi...

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Bibliographic Details
Main Authors: Menghui Gao, Yuchen He, Haosheng Tang, Xiangyu Chen, Shuang Liu, Yongguang Tao
Format: Article
Language:English
Published: Springer 2020-09-01
Series:Molecular Biomedicine
Subjects:
cGAS
STING
DNA sensor
Immune
Nuclei
Micronuclei
Online Access:https://doi.org/10.1186/s43556-020-00006-z

Internet

https://doi.org/10.1186/s43556-020-00006-z

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