Topical VEGF-C/D Inhibition Prevents Lymphatic Vessel Ingrowth into Cornea but Does Not Improve Corneal Graft Survival

Topical VEGF-C/D Inhibition Prevents Lymphatic Vessel Ingrowth into Cornea but Does Not Improve Corneal Graft Survival

Vascular endothelial growth factor-C/D (VEGF-C/D) regulates lymphangiogenesis. Ingrowth of lymphatic vessels is negatively associated with corneal transplantation success. In this study, we therefore analyzed the effect local blockade of VEGF-C/D has on inflamed corneas. We used the murine model of...

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Bibliographic Details
Main Authors: Ann-Charlott Salabarria, Manuel Koch, Alfrun Schönberg, Elisabeth Zinser, Deniz Hos, Matthias Hamdorf, Thomas Imhof, Gabriele Braun, Claus Cursiefen, Felix Bock
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Journal of Clinical Medicine
Subjects:
VEGF C/D trap
corneal transplantation
local immune modulation
Online Access:https://www.mdpi.com/2077-0383/9/5/1270

Internet

https://www.mdpi.com/2077-0383/9/5/1270

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