Multi-Target Inhibition of Cancer Cell Growth by SiRNA Cocktails and 5-Fluorouracil Using Effective Piperidine-Terminated Phosphorus Dendrimers

Multi-Target Inhibition of Cancer Cell Growth by SiRNA Cocktails and 5-Fluorouracil Using Effective Piperidine-Terminated Phosphorus Dendrimers

Currently, RNAi based approaches for cancer treatment involving short double stranded RNA molecules (siRNA) are under vigorous scrutinization. Due to numerous biological obstacles, siRNA delivery into target cells requires protective escort. On the other hand, combining of siRNA-mediated gene silenc...

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Bibliographic Details
Main Authors: Aliaksei Ihnatsyeu-Kachan, Volha Dzmitruk, Evgeny Apartsin, Olga Krasheninina, Maksim Ionov, Svetlana Loznikova, Alya Venyaminova, Katarzyna Miłowska, Dzmitry Shcharbin, Serge Mignani, Maria Angeles Muñoz-Fernández, Jean-Pierre Majoral, Maria Bryszewska
Format: Article
Language:English
Published: MDPI AG 2017-11-01
Series:Colloids and Interfaces
Subjects:
phosphorus dendrimers
siRNA
5-fluorouracil
cancer
combination therapy
Online Access:https://www.mdpi.com/2504-5377/1/1/6

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https://www.mdpi.com/2504-5377/1/1/6

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