R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in neurofibromin-null MPNST cells

R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in neurofibromin-null MPNST cells

Abstract Background Loss of the Ras GTPase-activating protein neurofibromin promotes nervous system tumor pathogenesis in patients with neurofibromatosis type 1 (NF1). Neurofibromin loss potentially hyperactivates classic Ras (H-Ras, N-Ras, K-Ras), M-Ras, and R-Ras (R-Ras, R-Ras2/TC21) subfamily pro...

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Bibliographic Details
Main Authors: Shannon M. Weber, Nicole M. Brossier, Amanda Prechtl, Stephen Barnes, Landon S. Wilson, Stephanie N. Brosius, Jody Fromm Longo, Steven L. Carroll
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Cell Communication and Signaling
Subjects:
Neurofibromatosis
Malignant peripheral nerve sheath tumor
Ras
R-Ras
TC21
Online Access:https://doi.org/10.1186/s12964-021-00773-4

Internet

https://doi.org/10.1186/s12964-021-00773-4

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