Induction of Cell Cycle and NK Cell Responses by Live-Attenuated Oral Vaccines against Typhoid Fever

Induction of Cell Cycle and NK Cell Responses by Live-Attenuated Oral Vaccines against Typhoid Fever

The mechanisms by which oral, live-attenuated vaccines protect against typhoid fever are poorly understood. Here, we analyze transcriptional responses after vaccination with Ty21a or vaccine candidate, M01ZH09. Alterations in response profiles were related to vaccine-induced immune responses and sub...

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Bibliographic Details
Main Authors: Christoph J. Blohmke, Jennifer Hill, Thomas C. Darton, Matheus Carvalho-Burger, Andrew Eustace, Claire Jones, Fernanda Schreiber, Martin R. Goodier, Gordon Dougan, Helder I. Nakaya, Andrew J. Pollard
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Immunology
Subjects:
typhoid
typhoid vaccines
functional genomics
vaccine immunity
Ty21a
NK cell
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01276/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01276/full

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