New Insights into Protein Kinase B/Akt Signaling: Role of Localized Akt Activation and Compartment-Specific Target Proteins for the Cellular Radiation Response

New Insights into Protein Kinase B/Akt Signaling: Role of Localized Akt Activation and Compartment-Specific Target Proteins for the Cellular Radiation Response

Genetic alterations driving aberrant activation of the survival kinase Protein Kinase B (Akt) are observed with high frequency during malignant transformation and cancer progression. Oncogenic gene mutations coding for the upstream regulators or Akt, e.g., growth factor receptors, RAS and phosphatid...

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Bibliographic Details
Main Authors: Klaudia Szymonowicz, Sebastian Oeck, Nathalie M. Malewicz, Verena Jendrossek
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:Cancers
Subjects:
Protein Kinase B
Akt
PI3K
cellular radiation response
signaling network
Akt targets
Online Access:http://www.mdpi.com/2072-6694/10/3/78

Internet

http://www.mdpi.com/2072-6694/10/3/78

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