Irisin Ameliorates Glucolipotoxicity-Associated β-Cell Dysfunction and Apoptosis via AMPK Signaling and Anti-Inflammatory Actions

Irisin Ameliorates Glucolipotoxicity-Associated β-Cell Dysfunction and Apoptosis via AMPK Signaling and Anti-Inflammatory Actions

Background/Aims: Islet metabolic disorder and inflammation contribute to the pathogenesis and progression of type 2 diabetes mellitus (T2DM). Irisin is a recently identified adipomyokine with protective effects on metabolic homeostasis and inflammation-suppressing effects in hepatic and vascular cel...

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Bibliographic Details
Main Authors: Dan Zhang, Ting Xie, Po Sing Leung
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-11-01
Series:Cellular Physiology and Biochemistry
Subjects:
Ins-1E cells
Insulin
Islets
Lipid metabolism
Nuclear factor-κB
Pancreas
Triglyceride
Diabetes mellitus
Online Access:https://www.karger.com/Article/FullText/495395

Internet

https://www.karger.com/Article/FullText/495395

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