Construction of a Novel Constitutively Active Chimeric EGFR to Identify New Targets for Therapy

Construction of a Novel Constitutively Active Chimeric EGFR to Identify New Targets for Therapy

Tumor cells and tumor-associated endothelial cells express activated epidermal growth factor receptor (EGFR) due to production of EGF-related ligands in the tumor microenvironment. To investigate the effect of perpetual EGFR activation on endothelial cells, we developed a novel method to generate c...

Full description

Bibliographic Details
Main Authors: Hua Cheng, Robert R. Langley, Qiuyu Wu, Wenjuan Wu, Jie Feng, Rachel Tsan, Dominic Fan, Isaiah J. Fidler
Format: Article
Language:English
Published: Elsevier 2005-12-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
EGFR
Stat3
angiogenesis
tumor endothelial cell
chimeric receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558605800430

Internet

http://www.sciencedirect.com/science/article/pii/S1476558605800430

Similar Items