Haloperidol affects bones while clozapine alters metabolic parameters - sex specific effects in rats perinatally treated with phencyclidine

Haloperidol affects bones while clozapine alters metabolic parameters - sex specific effects in rats perinatally treated with phencyclidine

Abstract Background The presentation of schizophrenia (SCH) symptoms differs between the sexes. Long-term treatment with antipsychotics is frequently associated with decreased bone mineral density, increased fracture risk and metabolic side effects. Perinatal phencyclidine (PCP) administration to ro...

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Bibliographic Details
Main Authors: Tatjana Nikolić, Milan Petronijević, Jelena Sopta, Milica Velimirović, Tihomir Stojković, Gordana Jevtić Dožudić, Milan Aksić, Nevena V. Radonjić, Nataša Petronijević
Format: Article
Language:English
Published: BMC 2017-10-01
Series:BMC Pharmacology and Toxicology
Subjects:
Schizophrenia
Bone mineral density
Haloperidol
Clozapine
Corticosterone
Phencyclidine
Online Access:http://link.springer.com/article/10.1186/s40360-017-0171-4

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http://link.springer.com/article/10.1186/s40360-017-0171-4

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