Heterocellular contacts with mouse brain endothelial cells via laminin and α6β1 integrin sustain subventricular zone (SVZ) stem/progenitor cells properties.

Heterocellular contacts with mouse brain endothelial cells via laminin and α6β1 integrin sustain subventricular zone (SVZ) stem/progenitor cells properties.

Neurogenesis in the subventricular zone (SVZ) is regulated by diffusible factors and cell-cell contacts. In vivo, SVZ stem cells are associated with the abluminal surface of blood vessels and such interactions are thought to regulate their neurogenic capacity. SVZ neural stem cells have been describ...

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Bibliographic Details
Main Authors: Alexandra Isabel Rosa, Sofia Grade, Sofia Duque Santos, Liliana Bernardino, Thomas C Chen, João Relvas, Florence M Hofman, Fabienne Agasse
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-12-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Laminin
Neurogenesis
SVZ
Stemness
α6β1 Integrin
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00284/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00284/full

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