Apolipoprotein A5 alleviates LPS/d-GalN-induced fulminant liver failure in mice by inhibiting TLR4-mediated NF-κB pathway

Apolipoprotein A5 alleviates LPS/d-GalN-induced fulminant liver failure in mice by inhibiting TLR4-mediated NF-κB pathway

Abstract Background Fulminant liver failure (FHF) is a serious clinical problem and liver transplantation is the major intervention. But the overall survival rate of FHF is low owing to the donated organ shortage. Apolipoprotein A-V (ApoA5) is a regulator of triglyceride metabolism and has been repo...

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Bibliographic Details
Main Authors: Ya-Chao Tao, Meng-Lan Wang, Dong-Bo Wu, Chen Luo, Hong Tang, En-Qiang Chen
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Journal of Translational Medicine
Subjects:
Apolipoprotein A-V
Fulminant liver failure
Lipopolysaccharide
Endotoxemia
TLR4
Online Access:http://link.springer.com/article/10.1186/s12967-019-1900-9

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http://link.springer.com/article/10.1186/s12967-019-1900-9

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