Glycolic Acid-Catalyzed Deamidation of Asparagine Residues in Degrading PLGA Matrices: A Computational Study

Glycolic Acid-Catalyzed Deamidation of Asparagine Residues in Degrading PLGA Matrices: A Computational Study

Poly(lactic-co-glycolic acid) (PLGA) is a strong candidate for being a drug carrier in drug delivery systems because of its biocompatibility and biodegradability. However, in degrading PLGA matrices, the encapsulated peptide and protein drugs can undergo various degradation reactions, including deam...

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Bibliographic Details
Main Authors:	Noriyoshi Manabe, Ryota Kirikoshi, Ohgi Takahashi
Format:	Article
Language:	English
Published:	MDPI AG 2015-03-01
Series:	International Journal of Molecular Sciences
Subjects:	peptide and protein drugs asparagine residue deamidation succinimide PLGA glycolic acid catalysis computational chemistry double proton transfer concerted bond reorganization
Online Access:	http://www.mdpi.com/1422-0067/16/4/7261

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