Glycolic Acid-Catalyzed Deamidation of Asparagine Residues in Degrading PLGA Matrices: A Computational Study

Glycolic Acid-Catalyzed Deamidation of Asparagine Residues in Degrading PLGA Matrices: A Computational Study

Poly(lactic-co-glycolic acid) (PLGA) is a strong candidate for being a drug carrier in drug delivery systems because of its biocompatibility and biodegradability. However, in degrading PLGA matrices, the encapsulated peptide and protein drugs can undergo various degradation reactions, including deam...

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Bibliographic Details
Main Authors: Noriyoshi Manabe, Ryota Kirikoshi, Ohgi Takahashi
Format: Article
Language:English
Published: MDPI AG 2015-03-01
Series:International Journal of Molecular Sciences
Subjects:
peptide and protein drugs
asparagine residue
deamidation
succinimide
PLGA
glycolic acid catalysis
computational chemistry
double proton transfer
concerted bond reorganization
Online Access:http://www.mdpi.com/1422-0067/16/4/7261

Internet

http://www.mdpi.com/1422-0067/16/4/7261

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