A Mitochondrial Polymorphism Alters Immune Cell Metabolism and Protects Mice from Skin Inflammation

A Mitochondrial Polymorphism Alters Immune Cell Metabolism and Protects Mice from Skin Inflammation

Several genetic variants in the mitochondrial genome (mtDNA), including ancient polymorphisms, are associated with chronic inflammatory conditions, but investigating the functional consequences of such mtDNA polymorphisms in humans is challenging due to the influence of many other polymorphisms in b...

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Bibliographic Details
Main Authors: Paul Schilf, Axel Künstner, Michael Olbrich, Silvio Waschina, Beate Fuchs, Christina E. Galuska, Anne Braun, Kerstin Neuschütz, Malte Seutter, Katja Bieber, Lars Hellberg, Christian Sina, Tamás Laskay, Jan Rupp, Ralf J. Ludwig, Detlef Zillikens, Hauke Busch, Christian D. Sadik, Misa Hirose, Saleh M. Ibrahim
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
conplastic mice
mtDNA polymorphisms
mitochondria
immunometabolism
metabolomics
autoimmune disease
Online Access:https://www.mdpi.com/1422-0067/22/3/1006

Internet

https://www.mdpi.com/1422-0067/22/3/1006

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