Transfer of PBMC From SSc Patients Induces Autoantibodies and Systemic Inflammation in Rag2-/-/IL2rg-/- Mice

Transfer of PBMC From SSc Patients Induces Autoantibodies and Systemic Inflammation in Rag2-/-/IL2rg-/- Mice

ObjectiveThe contribution of sustained autologous autoantibody production by B cells to the pathogenesis of systemic sclerosis (SSc) and granulomatosis with polyangiitis (GPA) is not fully understood. To investigate this, a humanized mouse model was generated by transferring patient-derived peripher...

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Bibliographic Details
Main Authors: Xiaoyang Yue, Frank Petersen, Yaqing Shu, Brigitte Kasper, Junie D. Tchudjin Magatsin, Marjan Ahmadi, Junping Yin, Jacqueline Wax, Xiaoqing Wang, Harald Heidecke, Peter Lamprecht, Antje Müller, Xinhua Yu, Gabriela Riemekasten
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
autoimmune diseases
systemic sclerosis
granulomatosis with polyangiitis
peripheral blood mononuclear cells
autoantibodies
systemic inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.677970/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.677970/full

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