Targeting the glucagon receptor improves cardiac function and enhances insulin sensitivity following a myocardial infarction

Targeting the glucagon receptor improves cardiac function and enhances insulin sensitivity following a myocardial infarction

Abstract Background In heart failure the myocardium becomes insulin resistant which negatively influences cardiac energy metabolism and function, while increasing cardiac insulin signalling improves cardiac function and prevents adverse remodelling in the failing heart. Glucagon’s action on cardiac...

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Bibliographic Details
Main Authors: Qutuba G. Karwi, Liyan Zhang, Cory S. Wagg, Wang Wang, Manoj Ghandi, Dung Thai, Hai Yan, John R. Ussher, Gavin Y. Oudit, Gary D. Lopaschuk
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Cardiovascular Diabetology
Subjects:
Glucagon
Insulin signalling
Glucose oxidation
Insulin sensitivity
Branched chain amino acids
Myocardial infarction
Online Access:http://link.springer.com/article/10.1186/s12933-019-0806-4

Internet

http://link.springer.com/article/10.1186/s12933-019-0806-4

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