Temporal and partial inhibition of GLI1 in neural stem cells (NSCs) results in the early maturation of NSC derived oligodendrocytes in vitro

Temporal and partial inhibition of GLI1 in neural stem cells (NSCs) results in the early maturation of NSC derived oligodendrocytes in vitro

Abstract Background Oligodendrocytes are a type of glial cells that synthesize the myelin sheath around the axons and are critical for the nerve conduction in the CNS. Oligodendrocyte death and defects are the leading causes of several myelin disorders such as multiple sclerosis, progressive multifo...

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Bibliographic Details
Main Authors: Poommaree Namchaiw, Han Wen, Florian Mayrhofer, Olga Chechneva, Sangita Biswas, Wenbin Deng
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Stem Cell Research & Therapy
Subjects:
Oligodendrocyte
GANT61
Myelination
NSC
Sonic Hedgehog
SHH
Online Access:http://link.springer.com/article/10.1186/s13287-019-1374-y

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http://link.springer.com/article/10.1186/s13287-019-1374-y

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