A Helical Polypeptide‐Based Potassium Ionophore Induces Endoplasmic Reticulum Stress‐Mediated Apoptosis by Perturbing Ion Homeostasis

A Helical Polypeptide‐Based Potassium Ionophore Induces Endoplasmic Reticulum Stress‐Mediated Apoptosis by Perturbing Ion Homeostasis

Abstract Perturbation of potassium homeostasis can affect various cell functions and lead to the onset of programmed cell death. Although ionophores have been intensively used as an ion homeostasis disturber, the mechanisms of cell death are unclear and the bioapplicability is limited. In this study...

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Bibliographic Details
Main Authors: DaeYong Lee, Soo‐Hwan Lee, Ilkoo Noh, Eonju Oh, Hyunil Ryu, JongHoon Ha, SeongDong Jeong, Jisang Yoo, Tae‐Joon Jeon, Chae‐Ok Yun, Yeu‐Chun Kim
Format: Article
Language:English
Published: Wiley 2019-07-01
Series:Advanced Science
Subjects:
apoptosis
cancer therapy
ER stress
perturbed potassium homeostasis
potassium ionophore
Online Access:https://doi.org/10.1002/advs.201801995

Internet

https://doi.org/10.1002/advs.201801995

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