Induction of Cell Death, DNA Strand Breaks, and Cell Cycle Arrest in DU145 Human Prostate Carcinoma Cell Line by Benzo[a]pyrene and Benzo[a]pyrene-7,8-diol-9,10-epoxide

Induction of Cell Death, DNA Strand Breaks, and Cell Cycle Arrest in DU145 Human Prostate Carcinoma Cell Line by Benzo[a]pyrene and Benzo[a]pyrene-7,8-diol-9,10-epoxide

Benzo[a]pyrene (B[a]P), a polycyclic aromatic hydrocarbon, is a major environmental pollutant. In this study, the effects of this carcinogen/mutagen and one of its metabolites, benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE), on human prostate carcinoma cell line DU145, were examined. Cell viability, DN...

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Bibliographic Details
Main Authors: Richard D. Gragg, Ronald D. Thomas, Michael Abazinge, Cynthia Harris, Alicia Tucker, Selina F. Darling-Reed, Onyinye Nwagbara
Format: Article
Language:English
Published: MDPI AG 2007-03-01
Series:International Journal of Environmental Research and Public Health
Subjects:
Benzo[a]pyrene
benzo[a]pyrene-7
8-diol-9
10-epoxide
DU145
cell viability
DNA damage
cell cycle
Online Access:http://www.mdpi.com/1660-4601/4/1/10/

Internet

http://www.mdpi.com/1660-4601/4/1/10/

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