The ESCRT-III molecules regulate the apical targeting of bile salt export pump

The ESCRT-III molecules regulate the apical targeting of bile salt export pump

Abstract Background The bile salt export pump (BSEP) is a pivotal apical/canalicular bile salt transporter in hepatocytes that drives the bile flow. Defects in BSEP function and canalicular expression could lead to a spectrum of cholestatic liver diseases. One prominent manifestation of BSEP-associa...

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Bibliographic Details
Main Authors: Shang-Hsin Wu, Mei-Hwei Chang, Ya-Hui Chen, Hui-Lin Wu, Huey-Huey Chua, Chin-Sung Chien, Yen-Hsuan Ni, Hui-Ling Chen, Huey-Ling Chen
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Journal of Biomedical Science
Subjects:
Apical trafficking
Bile salt export pump
Cholestasis
CHMP5
ESCRT
Liver development
Online Access:https://doi.org/10.1186/s12929-020-00706-2

Internet

https://doi.org/10.1186/s12929-020-00706-2

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