Acute Kidney Injury Induced Lupus Exacerbation Through the Enhanced Neutrophil Extracellular Traps (and Apoptosis) in Fcgr2b Deficient Lupus Mice With Renal Ischemia Reperfusion Injury

Acute Kidney Injury Induced Lupus Exacerbation Through the Enhanced Neutrophil Extracellular Traps (and Apoptosis) in Fcgr2b Deficient Lupus Mice With Renal Ischemia Reperfusion Injury

Renal ischemia is the most common cause of acute kidney injury (AKI) that might be exacerbate lupus activity through neutrophil extracellular traps (NETs) and apoptosis. Here, the renal ischemia reperfusion injury (I/R) was performed in Fc gamma receptor 2b deficient (Fcgr2b-/-) lupus mice and the i...

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Bibliographic Details
Main Authors: Wilasinee Saisorn, Supichcha Saithong, Pornpimol Phuengmaung, Kanyarat Udompornpitak, Thansita Bhunyakarnjanarat, Peerapat Visitchanakun, Awirut Chareonsappakit, Prapaporn Pisitkun, Direkrit Chiewchengchol, Asada Leelahavanichkul
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
Fcgr2b deficient mice
systemic lupus erythematosus
neutrophil extracellular traps
renal ischemia reperfusion injury
acute kidney injury
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.669162/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.669162/full

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