Targeting of Both the c-Met and EGFR Pathways Results in Additive Inhibition of Lung Tumorigenesis in Transgenic Mice

Targeting of Both the c-Met and EGFR Pathways Results in Additive Inhibition of Lung Tumorigenesis in Transgenic Mice

EGFR and c-Met are both overexpressed in lung cancer and initiate similar downstream signaling, which may be redundant. To determine how frequently ligands that initiate signaling of both pathways are found in lung cancer, we analyzed serum for hepatocyte growth factor (HGF), transforming growth fac...

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Bibliographic Details
Main Authors: Autumn L. Gaither-Davis, Jill M. Siegfried, K. Jin Kim, Naftali Kaminski, Stephanie R. Land, Diana Lenzner, Phouthone Keohavong, Mary E. Rothstein, Laura P. Stabile
Format: Article
Language:English
Published: MDPI AG 2010-12-01
Series:Cancers
Subjects:
lung cancer
EGFR
HGF
c-Me
Online Access:http://www.mdpi.com/2072-6694/2/4/2153/

Internet

http://www.mdpi.com/2072-6694/2/4/2153/

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