A first-passage approach to diffusion-influenced reversible binding and its insights into nanoscale signaling at the presynapse

Abstract Synaptic transmission between neurons is governed by a cascade of stochastic calcium ion reaction–diffusion events within nerve terminals leading to vesicular release of neurotransmitter. Since experimental measurements of such systems are challenging due to their nanometer and sub-millisec...

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Bibliographic Details
Main Authors: Maria Reva, David A. DiGregorio, Denis S. Grebenkov
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-84340-4