NOD2-mediated suppression of CD55 on neutrophils enhances C5a generation during polymicrobial sepsis.
Nucleotide-binding oligomerization domain (NOD) 2 is a cytosolic protein that plays a defensive role in bacterial infection by sensing peptidoglycans. C5a, which has harmful effects in sepsis, interacts with innate proteins. However, whether NOD2 regulates C5a generation during sepsis remains to be...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-05-01
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| Series: | PLoS Pathogens |
| Online Access: | http://europepmc.org/articles/PMC3649968?pdf=render |