In vitro activity of 1H-phenalen-1-one derivatives against Leishmania spp. and evidence of programmed cell death

In vitro activity of 1H-phenalen-1-one derivatives against Leishmania spp. and evidence of programmed cell death

Abstract Background The in vitro activity against Leishmania spp. of a novel group of compounds, phenalenone derivatives, is described in this study. Previous studies have shown that some phenalenones present leishmanicidal activity, and induce a decrease in the mitochondrial membrane potential in L...

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Bibliographic Details
Main Authors: Atteneri López-Arencibia, María Reyes-Batlle, Mónica B. Freijo, Ines Sifaoui, Carlos J. Bethencourt-Estrella, Aitor Rizo-Liendo, Olfa Chiboub, Grant McNaughton-Smith, Jacob Lorenzo-Morales, Teresa Abad-Grillo, José E. Piñero
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Parasites & Vectors
Subjects:
Leishmania donovani
Leishmania amazonensis
Phenalenones
Chemotherapy
Apoptosis-like
Online Access:https://doi.org/10.1186/s13071-019-3854-4

Internet

https://doi.org/10.1186/s13071-019-3854-4

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