Dehydroepiandrosterone Antagonizes Pain Stress-Induced Suppression of Testosterone Production in Male Rats

Dehydroepiandrosterone Antagonizes Pain Stress-Induced Suppression of Testosterone Production in Male Rats

Background: Leydig cells secrete the steroid hormone, testosterone, which is essential for male fertility and reproductive health. Stress increases the secretion of glucocorticoid [corticosterone, (CORT) in rats] that decreases circulating testosterone levels in part through a direct action on its r...

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Bibliographic Details
Main Authors: Qiqi Zhu, Fei Ge, Xiaoheng Li, Hou-Sheng Deng, Miao Xu, Tiao Bu, Jingyang Li, Yiyan Wang, Yuanyuan Shan, Ren-Shan Ge, Ming Yao
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Pharmacology
Subjects:
acute stress
pain
Leydig cell
steroidogenic enzymes
DHEA
corticosterone
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00322/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2018.00322/full

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