Mining mutation contexts across the cancer genome to map tumor site of origin
The vast majority of somatic mutations observed in tumors are rare. Here, the authors show that these large numbers of rare mutations are more predictive of the tissue of origin of a tumor than the information from a few common driver mutations.
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2021-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-23094-z |