Comparative Evaluation of Novel <sup>177</sup>Lu-Labeled PNA Probes for Affibody-Mediated PNA-Based Pretargeting

Comparative Evaluation of Novel <sup>177</sup>Lu-Labeled PNA Probes for Affibody-Mediated PNA-Based Pretargeting

Affibody-mediated PNA-based pretargeting is a promising approach to radionuclide therapy of HER2-expressing tumors. In this study, we test the hypothesis that shortening the PNA pretargeting probes would increase the tumor-to-kidney dose ratio. The primary probe Z<sub>HER2:342</sub>-SR-&...

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Bibliographic Details
Main Authors: Hanna Tano, Maryam Oroujeni, Anzhelika Vorobyeva, Kristina Westerlund, Yongsheng Liu, Tianqi Xu, Daniel Vasconcelos, Anna Orlova, Amelie Eriksson Karlström, Vladimir Tolmachev
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cancers
Subjects:
pretargeting
PNA
affibody molecules
radionuclide therapy
HER2-expressing xenografts
Online Access:https://www.mdpi.com/2072-6694/13/3/500

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https://www.mdpi.com/2072-6694/13/3/500

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