Top-Down Inhibition of BMP Signaling Enables Robust Induction of hPSCs Into Neural Crest in Fully Defined, Xeno-free Conditions

Top-Down Inhibition of BMP Signaling Enables Robust Induction of hPSCs Into Neural Crest in Fully Defined, Xeno-free Conditions

Defects in neural crest development have been implicated in many human disorders, but information about human neural crest formation mostly depends on extrapolation from model organisms. Human pluripotent stem cells (hPSCs) can be differentiated into in vitro counterparts of the neural crest, and so...

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Bibliographic Details
Main Authors: James O.S. Hackland, Tom J.R. Frith, Oliver Thompson, Ana Marin Navarro, Martin I. Garcia-Castro, Christian Unger, Peter W. Andrews
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Stem Cell Reports
Subjects:
neural crest
BMP
ectoderm
human pluripotent stem cells
embryonic stem cells
top-down inhibition
TDi
endogenous signal control
fully defined differentiation
Online Access:http://www.sciencedirect.com/science/article/pii/S221367111730365X

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http://www.sciencedirect.com/science/article/pii/S221367111730365X

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