MONOMERIC ß-AMYLOID INTERACTS WITH TYPE-1 INSULIN-LIKE GROWTH FACTOR RECEPTORS TO PROVIDE ENERGY SUPPLY TO NEURONS

MONOMERIC ß-AMYLOID INTERACTS WITH TYPE-1 INSULIN-LIKE GROWTH FACTOR RECEPTORS TO PROVIDE ENERGY SUPPLY TO NEURONS

ß-amyloid (Aß1-42) is produced by proteolytic cleavage of the transmembrane type-1 protein, amyloid precursor protein. Under pathological conditions, Aß1-42 self-aggregates into oligomers, which cause synaptic dysfunction and neuronal loss, and are considered the culprit of Alzheimer’s disease (AD)....

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Main Authors: Maria Laura eGiuffrida, Marianna Flora Tomasello, Giuseppe ePandini, Filippo eCaraci, Giuseppe eBattaglia, Carla eBusceti, Paola eDi Pietro, Giuseppe ePappalardo, Francesco eAttanasio, Santina eChiechio, Silvia eBagnoli, Benedetta eNacmias, Sandro eSorbi, Riccardo eVigneri, Enrico eRizzarelli, Ferdinando eNicoletti, Agata eCopani
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-08-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Glucose
Alzheimer’s disease
IGF-IR
ß-amyloid
GLUT3
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00297/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00297/full

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