Incubation of MDCO-216 (ApoA-IMilano/POPC) with Human Serum Potentiates ABCA1-Mediated Cholesterol Efflux Capacity, Generates New Prebeta-1 HDL, and Causes an Increase in HDL Size

Incubation of MDCO-216 (ApoA-IMilano/POPC) with Human Serum Potentiates ABCA1-Mediated Cholesterol Efflux Capacity, Generates New Prebeta-1 HDL, and Causes an Increase in HDL Size

MDCO-216 is a complex of dimeric ApoA-IMilano and palmitoyl oleoyl phosphatidylcholine (POPC), previously shown to reduce atherosclerotic plaque burden. Here we studied the effect of incubation of human plasma or serum with MDCO-216 on cholesterol efflux capacity from J774 cells, on prebeta-1 high d...

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Bibliographic Details
Main Authors: Herman J. Kempen, Dorota B. Schranz, Bela F. Asztalos, James Otvos, Elias Jeyarajah, Denise Drazul-Schrader, Heidi L. Collins, Steven J. Adelman, Peter L. J. Wijngaard
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:Journal of Lipids
Online Access:http://dx.doi.org/10.1155/2014/923903

Internet

http://dx.doi.org/10.1155/2014/923903

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