Labeling and Characterization of Human GLP-1-Secreting L-cells in Primary Ileal Organoid Culture

Labeling and Characterization of Human GLP-1-Secreting L-cells in Primary Ileal Organoid Culture

Summary: Glucagon-like peptide-1 (GLP-1) from intestinal L-cells stimulates insulin secretion and reduces appetite after food ingestion, and it is the basis for drugs against type-2 diabetes and obesity. Drugs targeting L- and other enteroendocrine cells are under development, with the aim to mimic...

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Bibliographic Details
Main Authors: Deborah A. Goldspink, Van B. Lu, Emily L. Miedzybrodzka, Christopher A. Smith, Rachel E. Foreman, Lawrence J. Billing, Richard G. Kay, Frank Reimann, Fiona M. Gribble
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Cell Reports
Subjects:
organoids
GLP-1
L-cells
CRISPR-Cas9
mass spectrometry
RNA sequencing
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720308147

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http://www.sciencedirect.com/science/article/pii/S2211124720308147

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