Intracellular and Tissue Levels of Vitamin B12 in Hepatocytes Are Modulated by CD320 Receptor and TCN2 Transporter

Intracellular and Tissue Levels of Vitamin B12 in Hepatocytes Are Modulated by CD320 Receptor and TCN2 Transporter

The liver mass constitutes hepatocytes expressing receptors for vitamin B12 (B12)-bound transporters in circulation. However, intrahepatic and circulating B12 interrelationship levels remain unclear. We assessed the intracellular B12 levels at various circulating B12 concentrations in human HepG2 ce...

Full description

Bibliographic Details
Main Authors:	Joseph Boachie, Antonysunil Adaikalakoteswari, Ilona Goljan, Jinous Samavat, Felino R. Cagampang, Ponnusamy Saravanan
Format:	Article
Language:	English
Published:	MDPI AG 2021-03-01
Series:	International Journal of Molecular Sciences
Subjects:	vitamin B12 (cobalamin), transcobalamin hepatocytes intrinsic factor B12 receptor (CD320), B12 transporter (transcobalamin II TCN2)
Online Access:	https://www.mdpi.com/1422-0067/22/6/3089

Similar Items

Corrigendum: Biomarkers and Algorithms for the Diagnosis of Vitamin B12 Deficiency
by: Luciana Hannibal, et al.
Published: (2017-08-01)

Long-term outcome of a patient with Transcobalamin deficiency caused by the homozygous c.1115_1116delCA mutation in TCN2 gene: a case report
by: Francesco Martino, et al.
Published: (2021-03-01)

Identification of transcobalamin deficiency with two novel mutations in the TCN2 gene in a Chinese girl with abnormal immunity: a case report
by: Shihong Zhan, et al.
Published: (2020-10-01)

A novel TCN2 mutation with unusual clinical manifestations of hemolytic crisis and unexplained metabolic acidosis: expanding the genotype and phenotype of transcobalamin II deficiency
by: Khongkraparn, A., et al.
Published: (2022)

Identification of differentially expressed proteins in vitamin B 12
by: Swati Varshney, et al.
Published: (2015-01-01)

Vitamin B<sub>12</sub> deficiency in the brain leads to DNA hypomethylation in the TCblR/CD320 knockout mouse
by: Fernàndez-Roig Sílvia, et al.
Published: (2012-05-01)

Low Vitamin B12 and Lipid Metabolism: Evidence from Pre-Clinical and Clinical Studies
by: Joseph Boachie, et al.
Published: (2020-06-01)

Fisiopatologia da deficiência de vitamina B12 e seu diagnóstico laboratorial Physiopathology of vitamin B12 deficiency and its laboratorial diagnosis
by: Clóvis Paniz, et al.
Published: (2005-10-01)

An update on vitamin B12-related gene polymorphisms and B12 status
by: S. Surendran, et al.
Published: (2018-02-01)

Genetic polymorphisms of vitamin B12 and folate transporter proteins and depression in postpartum period: A case-control study
by: Pooja Dhiman, et al.
Published: (2021-12-01)

Biological Activity of Pseudovitamin B<sub>12</sub> on Cobalamin-Dependent Methylmalonyl-CoA Mutase and Methionine Synthase in Mammalian Cultured COS-7 Cells
by: Tomohiro Bito, et al.
Published: (2020-07-01)

Vitamin B12: Unique Metalorganic Compounds and the Most Complex Vitamins
by: Lucio Randaccio, et al.
Published: (2010-04-01)

Response of Human Glioblastoma Cells to Vitamin B12 Deficiency: A Study Using the Non-Toxic Cobalamin Antagonist
by: Zuzanna Rzepka, et al.
Published: (2021-01-01)

Seminal but not Serum Levels of Holotranscobalamin are Altered in Morbid Obesity and Correlate with Semen Quality: A Pilot Single Centre Study
by: Jinous Samavat, et al.
Published: (2019-07-01)

Comparative Bioavailability of Synthetic B12 and Dietary Vitamin B12 Present in Cow and Buffalo Milk: A Prospective Study in Lactovegetarian Indians
by: Namita Mahalle, et al.
Published: (2019-02-01)

Differences in Tissue Distribution of Cyano–B12 and Hydroxo–B12 One Week after Oral Intake: An Experimental Study in Male Wistar Rats
by: Eva Greibe, et al.
Published: (2018-10-01)

Severe Haemolytic Anaemia, a Rare Presentation of Nutritional Vitamin B12 Deficiency: A Case Report
by: Aamir Siddiqui
Published: (2019-06-01)

Biological function of cobalamin: causes and effects of hypocobalaminemia at the molecular, cellular, tissue and organism level
by: Zuzanna Rzepka, et al.
Published: (2020-10-01)

B12 vitamin eksikliği olan hastalarda üst gastrointestinal endoskopi bulguları
by: Ufuk DEMİRCİ, et al.
Published: (2017-06-01)

Systematic Review and Pragmatic Clinical Approach to Oral and Nasal Vitamin B12 (Cobalamin) Treatment in Patients with Vitamin B12 Deficiency Related to Gastrointestinal Disorders
by: Emmanuel Andrès, et al.
Published: (2018-09-01)

Nutritional 1C Imbalance, B12 Tissue Accumulation, and Pregnancy Outcomes: An Experimental Study in Rats
by: Ole Nymark, et al.
Published: (2018-10-01)

Intracellular Processing of Cobalamins in Mammalian Cells
by: Hannibal, Luciana
Published: (2009)

Evaluation of Mean Platelet Volume Before and After Cobalamin Treatment in Patients with Vitamin B12 Deficiency
by: Suleyman Yuce, et al.
Published: (2014-04-01)

Neurological disorders in vitamin B12 deficiency
by: Ch S Pavlov, et al.
Published: (2019-04-01)

Diagnostic Associations of Hypercobalaminemia in Indian Population
by: Swarnima Singh, et al.
Published: (2020-10-01)

Vitamin B 12 Deficiency and Multiple Sclerosis; Is there Any Association?
by: Mohamad Reza Najafi, et al.
Published: (2012-01-01)

In Vitro Effect of Folic Acid and Cobalamin (Vitamin B12) on Adhesion and Growth of Giardia lamblia
by: R Khademi, et al.
Published: (2006-12-01)

Polymorphisms of Homocysteine Metabolism Are Associated with Intracranial Aneurysms
by: Semmler , Alexander, et al.
Published: (2014)

B12 Vitamin Eksikliği Olan Hastalarda Kobalamin Tedavisi Öncesi ve Sonrası Ortalama Trombosit Volümünün Değerlendirilmesi
by: Süleyman YÜCE, et al.
Published: (2014-07-01)

Cold Adaptation in Antarctic Notothenioids: Comparative Transcriptomics Reveals Novel Insights in the Peculiar Role of Gills and Highlights Signatures of Cobalamin Deficiency
by: Federico Ansaloni, et al.
Published: (2021-02-01)

Vitamin B12 concentrations and clinical spectrum of apparently healthy elderly population
by: Darshana Makwana 1 Deepak Kumar P2 , Pragathi Wadkar3
Published: (2020-04-01)

Vitamin B12 (Cobalamin) and Micronutrient Fortification in Food Crops Using Nanoparticle Technology
by: Soojin Oh, et al.
Published: (2021-08-01)

B12 as a Treatment for Peripheral Neuropathic Pain: A Systematic Review
by: Thomas Julian, et al.
Published: (2020-07-01)

B12 deficiency in India
by: P K Sasidharan
Published: (2017-01-01)

Vitamin B12 and Semen Quality
by: Saleem Ali Banihani
Published: (2017-06-01)

Effect of Oxidation Agents on Photo-Decolorization of Vitamin B<sub>12</sub> in the Presence of ZnO/UV-A System
by: Luma Majeed Ahmed, et al.
Published: (2018-05-01)

Current Nanocarrier Strategies Improve Vitamin B12 Pharmacokinetics, Ameliorate Patients’ Lives, and Reduce Costs
by: Marco Fidaleo, et al.
Published: (2021-03-01)

Optimisation de la quantification de la chlordécone et mise au point d'un procédé de dégradation par des matériaux hybrides charbons actifs-cobalamine.
by: Ranguin, Ronald
Published: (2015)

In Vitro Effect of Folic Acid and Cobalamin (Vitamin B12) on Adhesion and Growth of Giardia lamblia
by: H Dalimi Asl, et al.
Published: (2006-08-01)

Determination of vitamin B12 in dairy products by ultra performance liquid chromatography-tandem mass spectrometry
by: Elisa Zironi, et al.
Published: (2014-12-01)