The dynamic interplay of host and viral enzymes in type III CRISPR-mediated cyclic nucleotide signalling

The dynamic interplay of host and viral enzymes in type III CRISPR-mediated cyclic nucleotide signalling

Cyclic nucleotide second messengers are increasingly implicated in prokaryotic anti-viral defence systems. Type III CRISPR systems synthesise cyclic oligoadenylate (cOA) upon detecting foreign RNA, activating ancillary nucleases that can be toxic to cells, necessitating mechanisms to remove cOA in s...

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Bibliographic Details
Main Authors: Januka S Athukoralage, Shirley Graham, Christophe Rouillon, Sabine Grüschow, Clarissa M Czekster, Malcolm F White
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-04-01
Series:eLife
Subjects:
CRISPR
Sulfolobus solfataricus
cyclic oligoadenylate
ribonuclease
ring nuclease
Online Access:https://elifesciences.org/articles/55852

Internet

https://elifesciences.org/articles/55852

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