Identification and quantification of dolichol and dolichoic acid in neuromelanin from substantia nigra of the human brains⃞

Neuromelanin (NM) isolated from the substantia nigra of the human brain is found to contain a series of dolichoic acids (dol-CA) containing 14–20 isoprene units. This is the first observation of dol-CA in a natural system. Using internally spiked nor-dolichol and nor-dolichoic acid standards, the co...

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Bibliographic Details
Main Authors: Weslyn C. Ward, Ziqiang Guan, Fabio A. Zucca, Ruggero G. Fariello, Reza Kordestani, Luigi Zecca, Christian R.H. Raetz, John D. Simon
Format: Article
Language:English
Published: Elsevier 2007-07-01
Series:Journal of Lipid Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520425301