Phosphatidylinositol 3-kinase signaling in proliferating cells maintains an anti-apoptotic transcriptional program mediated by inhibition of FOXO and non-canonical activation of NFκB transcription factors

Phosphatidylinositol 3-kinase signaling in proliferating cells maintains an anti-apoptotic transcriptional program mediated by inhibition of FOXO and non-canonical activation of NFκB transcription factors

<p>Abstract</p> <p>Background</p> <p>Phosphatidylinositol (PI) 3-kinase is activated by a variety of growth factor receptors and the PI 3-kinase/Akt signaling pathway is a key regulator of cell proliferation and survival. The downstream targets of PI 3-kinase/Akt signal...

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Bibliographic Details
Main Authors: Adams Kenneth W, Graham Julie R, Terragni Jolyon, Schaffer Michael E, Tullai John W, Cooper Geoffrey M
Format: Article
Language:English
Published: BMC 2008-01-01
Series:BMC Cell Biology
Online Access:http://www.biomedcentral.com/1471-2121/9/6

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http://www.biomedcentral.com/1471-2121/9/6

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