pH Dependence of <i>T</i><sub>2</sub> for Hyperpolarizable <sup>13</sup>C-Labelled Small Molecules Enables Spatially Resolved pH Measurement by Magnetic Resonance Imaging

pH Dependence of <i>T</i><sub>2</sub> for Hyperpolarizable <sup>13</sup>C-Labelled Small Molecules Enables Spatially Resolved pH Measurement by Magnetic Resonance Imaging

Hyperpolarized <sup>13</sup>C magnetic resonance imaging often uses spin-echo-based pulse sequences that are sensitive to the transverse relaxation time <i>T</i><sub>2</sub>. In this context, local <i>T</i><sub>2</sub>-changes might introdu...

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Bibliographic Details
Main Authors: Martin Grashei, Christian Hundshammer, Frits H. A. van Heijster, Geoffrey J. Topping, Franz Schilling
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Pharmaceuticals
Subjects:
<i>T</i><sub>2</sub> relaxation time constant
pH
[1-<sup>13</sup>C]pyruvate
[1-<sup>13</sup>C]acetate
<sup>13</sup>C-labeled biomolecules
hyperpolarization
Online Access:https://www.mdpi.com/1424-8247/14/4/327

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