Unique pharmacological property of ISRIB in inhibition of Aβ-induced neuronal cell death

Unique pharmacological property of ISRIB in inhibition of Aβ-induced neuronal cell death

A pharmacological approach to ameliorate Alzheimer's disease (AD) has not yet been established. In the present study, we investigated the pharmacological characteristics of the recently identified memory-enhancing compound, ISRIB for the amelioration of AD. ISRIB potently attenuated amyloid β-i...

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Main Authors: Toru Hosoi, Mai Kakimoto, Keigo Tanaka, Jun Nomura, Koichiro Ozawa
Format: Article
Language:English
Published: Elsevier 2016-08-01
Series:Journal of Pharmacological Sciences
Subjects:
Amyloid β
Alzheimer's disease
ISRIB
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861316301013
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spelling doaj-afa03c346a17404ca04b281fd5ac1f722020-11-24T21:41:00ZengElsevierJournal of Pharmacological Sciences1347-86132016-08-01131429229510.1016/j.jphs.2016.08.003Unique pharmacological property of ISRIB in inhibition of Aβ-induced neuronal cell deathToru Hosoi0Mai Kakimoto1Keigo Tanaka2Jun Nomura3Koichiro Ozawa4Department of Pharmacotherapy, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, JapanDepartment of Pharmacotherapy, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, JapanDepartment of Pharmacotherapy, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, JapanRIKEN Brain Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, JapanDepartment of Pharmacotherapy, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, JapanA pharmacological approach to ameliorate Alzheimer's disease (AD) has not yet been established. In the present study, we investigated the pharmacological characteristics of the recently identified memory-enhancing compound, ISRIB for the amelioration of AD. ISRIB potently attenuated amyloid β-induced neuronal cell death at concentrations of 12.5–25 nM, but did not inhibit amyloid β production in the HEK293T cell line expressing the amyloid precursor protein (APP). These results suggest that ISRIB possesses the unique pharmacological property of attenuating amyloid β-induced neuronal cell death without affecting amyloid β production.http://www.sciencedirect.com/science/article/pii/S1347861316301013Amyloid βAlzheimer's diseaseISRIB
collection DOAJ
language English
format Article
sources DOAJ
author Toru Hosoi
Mai Kakimoto
Keigo Tanaka
Jun Nomura
Koichiro Ozawa
spellingShingle Toru Hosoi
Mai Kakimoto
Keigo Tanaka
Jun Nomura
Koichiro Ozawa
Unique pharmacological property of ISRIB in inhibition of Aβ-induced neuronal cell death
Journal of Pharmacological Sciences
Amyloid β
Alzheimer's disease
ISRIB
author_facet Toru Hosoi
Mai Kakimoto
Keigo Tanaka
Jun Nomura
Koichiro Ozawa
author_sort Toru Hosoi
title Unique pharmacological property of ISRIB in inhibition of Aβ-induced neuronal cell death
title_short Unique pharmacological property of ISRIB in inhibition of Aβ-induced neuronal cell death
title_full Unique pharmacological property of ISRIB in inhibition of Aβ-induced neuronal cell death
title_fullStr Unique pharmacological property of ISRIB in inhibition of Aβ-induced neuronal cell death
title_full_unstemmed Unique pharmacological property of ISRIB in inhibition of Aβ-induced neuronal cell death
title_sort unique pharmacological property of isrib in inhibition of aβ-induced neuronal cell death
publisher Elsevier
series Journal of Pharmacological Sciences
issn 1347-8613
publishDate 2016-08-01
description A pharmacological approach to ameliorate Alzheimer's disease (AD) has not yet been established. In the present study, we investigated the pharmacological characteristics of the recently identified memory-enhancing compound, ISRIB for the amelioration of AD. ISRIB potently attenuated amyloid β-induced neuronal cell death at concentrations of 12.5–25 nM, but did not inhibit amyloid β production in the HEK293T cell line expressing the amyloid precursor protein (APP). These results suggest that ISRIB possesses the unique pharmacological property of attenuating amyloid β-induced neuronal cell death without affecting amyloid β production.
topic Amyloid β
Alzheimer's disease
ISRIB
url http://www.sciencedirect.com/science/article/pii/S1347861316301013
work_keys_str_mv AT toruhosoi uniquepharmacologicalpropertyofisribininhibitionofabinducedneuronalcelldeath
AT maikakimoto uniquepharmacologicalpropertyofisribininhibitionofabinducedneuronalcelldeath
AT keigotanaka uniquepharmacologicalpropertyofisribininhibitionofabinducedneuronalcelldeath
AT junnomura uniquepharmacologicalpropertyofisribininhibitionofabinducedneuronalcelldeath
AT koichiroozawa uniquepharmacologicalpropertyofisribininhibitionofabinducedneuronalcelldeath
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