Unique pharmacological property of ISRIB in inhibition of Aβ-induced neuronal cell death

A pharmacological approach to ameliorate Alzheimer's disease (AD) has not yet been established. In the present study, we investigated the pharmacological characteristics of the recently identified memory-enhancing compound, ISRIB for the amelioration of AD. ISRIB potently attenuated amyloid β-i...

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Bibliographic Details
Main Authors: Toru Hosoi, Mai Kakimoto, Keigo Tanaka, Jun Nomura, Koichiro Ozawa
Format: Article
Language:English
Published: Elsevier 2016-08-01
Series:Journal of Pharmacological Sciences
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861316301013