Interaction of clinical-stage antibodies with heme predicts their physiochemical and binding qualities
Lecerf et al. examine over 100 samples with variable region sequences matching clinical-stage immunoglobulin antibodies, to demonstrate that many interact with heme. They find that those that do interact with heme possess specific sequence traits that manifest qualities such as increased hydrophobic...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2021-03-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-01931-7 |