Remodeling of active endothelial enhancers is associated with aberrant gene-regulatory networks in pulmonary arterial hypertension

Remodeling of active endothelial enhancers is associated with aberrant gene-regulatory networks in pulmonary arterial hypertension

Pulmonary arterial hypertension (PAH) is a heterogeneous disease, causing severe breathing problems and cardiac morbidity. Here, the authors study chromatin marks in pulmonary arterial endothelial cells from PAH patients and controls and find changes in transcription factor and enhancer activity tha...

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Bibliographic Details
Main Authors: Armando Reyes-Palomares, Mingxia Gu, Fabian Grubert, Ivan Berest, Silin Sa, Maya Kasowski, Christian Arnold, Mao Shuai, Rohith Srivas, Simon Miao, Dan Li, Michael P. Snyder, Marlene Rabinovitch, Judith B. Zaugg
Format: Article
Language:English
Published: Nature Publishing Group 2020-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15463-x

Internet

https://doi.org/10.1038/s41467-020-15463-x

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