Cryo-EM structures of remodeler-nucleosome intermediates suggest allosteric control through the nucleosome

Cryo-EM structures of remodeler-nucleosome intermediates suggest allosteric control through the nucleosome

The SNF2h remodeler slides nucleosomes most efficiently as a dimer, yet how the two protomers avoid a tug-of-war is unclear. Furthermore, SNF2h couples histone octamer deformation to nucleosome sliding, but the underlying structural basis remains unknown. Here we present cryo-EM structures of SNF2h-...

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Bibliographic Details
Main Authors: Jean Paul Armache, Nathan Gamarra, Stephanie L Johnson, John D Leonard, Shenping Wu, Geeta J Narlikar, Yifan Cheng
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-06-01
Series:eLife
Subjects:
chromatin remodeling
ISWI
CryoEM
smFRET
nucleosome
ATPase
Online Access:https://elifesciences.org/articles/46057

Internet

https://elifesciences.org/articles/46057

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