Generation and analysis of novel plant-derived antibody-based therapeutic molecules against West Nile virus.

Generation and analysis of novel plant-derived antibody-based therapeutic molecules against West Nile virus.

Previously, our group engineered a plant-derived monoclonal antibody (MAb) (pHu-E16) that efficiently treated West Nile virus (WNV) infection in mice. In this study, we developed several pHu-E16 variants to improve its efficacy. These variants included a single-chain variable fragment (scFv) of pHu-...

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Bibliographic Details
Main Authors: Junyun He, Huafang Lai, Michael Engle, Sergey Gorlatov, Clemens Gruber, Herta Steinkellner, Michael S Diamond, Qiang Chen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24675995/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24675995/?tool=EBI

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